Magnesium L-Threonate is an organically-bound magnesium salt formed by combining magnesium with L-threonic acid, a metabolite of vitamin C. Its CAS number is 778571-57-6, with a molecular formula of C₈H₁₄MgO₁₀ and a molecular weight of 294.5.
Magnesium L-Threonate was specifically developed to address a key limitation of traditional magnesium forms—poor brain bioavailability. Standard magnesium supplements, while effective at raising magnesium levels in the body, have limited ability to cross the blood-brain barrier, meaning they do not significantly increase magnesium concentrations within the brain where it is needed for cognitive and neurological functions.
Magnesium is an essential mineral that serves as a cofactor for over 300 enzymatic reactions in the human body, playing critical roles in energy generation, neuromuscular function, cardiovascular health, bone maintenance, and nervous system function . Unfortunately, approximately 50% of the US population and roughly 30% of the global population do not consume adequate dietary magnesium . Magnesium L-Threonate offers a targeted solution for those seeking to support both overall magnesium status and specific brain health benefits.
Greenhai Nutritionals Magnesium L-Threonate is manufactured under strict quality control standards, ensuring high purity and consistent quality. The European Food Safety Authority (EFSA) has concluded that Magnesium L-Threonate is safe under proposed conditions of use, with a maximum intake level of 1600 mg per day for adults, and has confirmed that magnesium from this source is bioavailable.
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| Items | Specification |
| Appearance | White or almost white powder |
| Identification | Positive |
| Assay | 98.0~102.0% |
| Magnesium | 7.2~8.3% |
| pH | 5.8~8.0 |
| Loss on drying | ≤ 1.0% |
| Lead | ≤ 0.5ppm |
| Arsenic | ≤ 1.0ppm |
| Mercury | ≤ 0.5ppm |
| Total Plate Count | ≤ 1,000cfu/g |
| Yeasts and Mold | ≤ 100cfu/g |
| E. Coli | Negative |
| Salmonella | Negative/25g |
| Coliform | Negative |
Magnesium L-Threonate has been shown to improve overall cognitive performance, working memory, and episodic memory. A 6-week randomized, double-blind, placebo-controlled trial demonstrated that supplementation with Magnesium L-Threonate was associated with a 7.5-year reduction in estimated brain cognitive age, along with significant improvements in reaction time compared to placebo . Animal studies have also shown it increases synapse density and memory ability in aged rats and Alzheimer’s disease model mice .
For individuals experiencing sleep difficulties, Magnesium L-Threonate has demonstrated significant benefits in both subjective and objective sleep measures. Clinical research shows that participants taking MgT experienced more deep sleep and REM sleep, as measured by sleep-tracking wearable devices, along with improved post-awakening behavior, mental alertness, and daytime functioning . These benefits are believed to be mediated through magnesium’s regulatory role in neurotransmitters such as GABA, which promotes relaxation, and its ability to improve neuroplasticity and synaptic function.
Supplementation with Magnesium L-Threonate has been associated with physiological markers of stress reduction and improved autonomic balance. Clinical trial data shows a significant reduction in resting heart rate and an increase in heart rate variability (HRV) during sleep, indicating enhanced parasympathetic nervous system activity and better stress resilience.
Research indicates that Magnesium L-Threonate may offer neuroprotective benefits. Studies have demonstrated its ability to reduce hippocampal amyloid-β load—a key pathological feature of Alzheimer’s disease—under both normal and hypothyroid conditions . Additionally, it has been shown to increase hippocampal BDNF (Brain-Derived Neurotrophic Factor) levels, a protein critical for neuronal survival, growth, and synaptic plasticity . These properties make it a valuable supplement for supporting long-term brain health and potentially mitigating age-related cognitive decline.
For more information, please contact 📧inquiry@greenhai.com if there is anything we can do for you.
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